Driving directions:

From Cairns: find Sheridan Street, the main road that goes through all of Cairns, and start heading north, Sheridan St. becomes the Cook Highway.
From Cairns airport or Port Douglas: turn right when you get to the highway and head north.
On the north side of Cairns you will go through at least a dozen roundabouts, if you are new to Australia remember that traffic entering the roundabout gives way to traffic that is already on the roundabout. On these roundabouts follow the signs for Mossman and Port Douglas.
After about one hour from Cairns you will pass Port Douglas on your right hand side, and another 15 minutes or so later you will pass through Mossman.
Keep heading north after Mossman and following the signs to Cape Tribulation. After 20 minutes or so you will see the sign below, indicating you will need to turn right to the ferry;

Once you are across the Daintree river it is another 36km. to Cape Tribulation, due to the speed limits and winding roads this can take you close to an hour, even without stops. Keep your speed down to save the wildlife, especially the cassowary.
On arrival in Cape Tribulation you will first see the signs for the Cape Trib shop/info centre, and 500 metre further the sign "Welcome to Cape Tribulation".
About 200 metres past this welcome sign turn left into Camelot Close, there is a sign on the corner pointing to Rainforest Hideaway.
If you arrive at night keep an eye out for the Ferntree Resort sign, this is the only one lit up on this corner.
Proceed up Camelot Close past the Dragonfly and Ferntree until you see the sign Rainforest Hideaway and the frog mailbox on your left.